I once listened from a very diferente perspective by accident and I will leave here my personal interpretation:
I hear it as if a very sad and disappointed Jesus (Christian God) was singing in the middle of something similar to an existential crisis but in cosmic level.
Finding Himself in a moment when, having the power to make things up from thin air, only pain is real (assuming that maybe He kept the ability to feel pain from when he was human).
Trying to kill all living things, everything, but is pointless because they would still live in His mind since He can literally remember "everything".
Humans where supposed to be his friends in a beginning, so "my sweetest friend" could be humanity listening or a single human, a kid probably.
Everyone leaves because we are not immortal like He is, and because most have stopped believing.
And this one could not be the first humanity he tried but his creation keeps leaving.
Now He feels like all He planned for humanity is as valuable as dirt, and that He left us all down, "hurting" people indirectly.
Still wearing the crown of thorns, metaphorically,and in a throne where people have put Him, a throne of lies since mostly people teach lies in His name beyond repair.
He has lived so much He has seen humanity change era by era but, as he stated once back then, He keeps the same no matter what.
"If I could start again a million miles away I would keep my self I would find a way" sounds like going back to His sacrifice, or maybe even before, back to the creation, and He would keep Himself from dying for people that would not care, or keep Himself from creating humanity, respectively to the time He means.
Keep in mind I'm not against or favoring an specific belief. This is said meaning no offense to anyone. I'm almost sure this is not the actual meaning, probably is just drugs, but I'm a writer, I have too much imagination floating around. Again, no offense, to anyone.
Sorry if typos, not my first language.
